Long-term survival in localised prostate cancer (CaP) can be achieved with treatment by either radical prostatectomy (RP) or external beam radiotherapy (EBRT). The development of second primary tumour is poorly understood in such cases. This retrospective study included 84,397 cases of localised prostate cancer treated by RP or EBRT between 1988 and 2009.

Thirty-nine percent were treated with RP and 61% with EBRT. The median follow-up was 69 months. One thousand and sixty-eight (2%) developed pelvic tumours, 1236 bladder cancer and 432 rectal cancer. Further analysis and data was also discussed in the article. Thus, patients with EBRT are at an increased risk of developing second primary bladder cancer as compared with RP. However, no difference was found in rectal cancer incidence. This study will be of interest to urologists and oncologists alike.

External beam radiotherapy increases the risk of bladder cancer when compared with radical prostatectomy in patients affected by prostate cancer: a population-based analysis.
Moschini M, Zaffuto E, Karakiewicz PI, et al.
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Arun K Sharma

West Herts NHS Trust (Watford General Hospital)

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