The 2010 American Urological Association (AUA) guidelines on primary vesicoureteral reflux (VUR) state that children with VUR and lower urinary tract dysfunction are less likely to have the VUR resolve spontaneously than those with primary VUR alone (31% vs. 61%). These authors summarise their experience of treating VUR associated with lower urinary tract dysfunction in 15 patients (22 ureters, mean patient age 6.1 years, range 4-12) with between one to three injections of Deflux. Reflux resolved in 17 ureters (77%) including eight out of nine where there was dysfunctional voiding and five of nine with idiopathic detrusor overactivity. The authors conclude that, despite accepted knowledge that the success rates of Deflux injection in children with lower urinary tract dysfunction is lower than if this dysfunction was not present, clinicians should not avoid utilising Deflux in these circumstances, given that a success rate of over 50% was achieved. 

Outcomes of vesicoureteral reflux in children with non – neurogenic dysfunction treated with dextranomer / hyluronic acid and copolymer (Deflux).
Van Batavia J, Nees S, Fast A, et al.
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Henrik Steinbrecher

Southampton University Hospital NHS Trust

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