This article from the west of Germany will be of interest to many of us who use alpha-blockers for bladder outflow symptoms. The classic model of understanding of alpha receptors has been challenged recently. Further models have been identified, including intracellular mediators of contraction, non-contractile signalling and post-translational regulation. In short, the prostate alpha receptor is no longer an isolated receptor. It may be just part of a complex network of intra / su-cellular mechanisms. The paper is supported by 144 references.