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The potential of statin use in castrate resistant prostate cancer treatment

One of the mechanisms by which prostate cancer achieves castrate resistance is through de novo intratumoral production of androgens. Reactivation of androgen receptors results in promotion of cell survival and proliferation pathways despite castrate serum testosterone levels. As androgen synthesis...

BURST @ BAUS25

By Quentin Mak, Head of Secretariat; Aqua Asif, Head of Communications; Cameron Alexander, Co Vice-Chair; and Arjun Nathan, Co- Chair, BURST. BAUS is a cornerstone in the British Urological Researchers in Surgical Training (BURST) calendar. The conference offers BURST the...

Urology National Selection: tips and tricks for a successful interview process

We invited Dominic Brown, the top-ranking candidate from the Urology National Training Selection Interview 2023, to share his wisdom on the interview process. Dominic is currently an ST3 working in North West London. Kelly Ong, Urology News Trainees Sub-Editor. 1....

Improving on the Rotterdam Prostate Cancer Risk Calculator

Following the PROMIS trial [1], many cancer centres in the UK are now offering pre-biopsy multiparametric MRI (mpMRI) for men suitable for radical treatment. The European Association of Urology for Prostate Cancer (PCa) guidelines recommend individual risk stratification before the...

Urological trauma – part 2

Part 1 of this topic is available here. Case 1 A 29-year-old male was attacked and kicked in his left flank. He presented to the emergency department with left flank pain and frank haematuria. He remained haemodynamically stable. 1. What...

Millions of women in their 40s are SUFFERING with bladder leakage

Two thirds of women over 40 are currently SUFFERING with bladder leakage – with many feeling EMBARRASSED and DEPRESSED as a direct result, a study found. The condition, which can be caused by childbirth and often develops as women get older, is believed to affect MILLIONS of females - of all ages.

Sustainable healthcare: what steps can urologists take?

Human health is intrinsically linked to environmental health, making the ever-pressing climate crisis fundamentally a public health emergency. The healthcare sector is responsible for 8% of the UK’s greenhouse gas (GHG) emissions worldwide [1]. As the largest publicly funded healthcare...

Prostate Cancer UK: PSA Consensus Conference 2024

During the conference, you'll get up-to-date information on the latest consensus regarding the PSA blood test. You'll also be able to discuss the diagnostic process for secondary care and learn how to proactively manage conversations about prostate health with patients who are at higher risk. You’ll have plenty of opportunities to ask questions, interact with peers, and apply what you learn through engaging case studies. 9am – 12.30pm

Dundee Institute for Healthcare Simulation: Fundamentals of Transurethral Resection and Ureteroscopic Skills using animal and human Cadaveric models.

This is a one and a half day practical course, ideal for Urology Trainees who are already undertaking or about to start training in endoscopic urology. The emphasis during the course will be hands-on training mainly on restructured animal tissue models and also Thiel embalmed human cadavers, whilst the relevant key clinical elements will be addressed by the experts in the subject areas. The course will be taught by consultant urologists. The atmosphere is relaxed and informal, allowing easy exchange of ideas and experiences.

The final hurdle: the consultant interview

The consultant interview is undoubtedly the most important exam you’ll ever sit; but curiously even the best and most motivated trainee becomes somewhat fatalistic when approaching this, the most important of all hurdles. Gone are the days when deals were...

Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer

Abiraterone acetate, the prodrug of abiraterone, blocks endogenous androgen synthesis by inhibiting cytochrome p-450c17, a critical enzyme in androgen biosynthesis. Its active D4A metabolite also has anti-tumour effects through possibly multiple mechanisms. 3-5% of men diagnosed with prostate cancer in...