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The potential of statin use in castrate resistant prostate cancer treatment
One of the mechanisms by which prostate cancer achieves castrate resistance is through de novo intratumoral production of androgens. Reactivation of androgen receptors results in promotion of cell survival and proliferation pathways despite castrate serum testosterone levels. As androgen synthesis...Metabolic stone disease for urology trainees
Urolithiasis continues to be a heavy burden on the worldwide medical infrastructure with an estimated 106 million cases recorded internationally in 2021 [1]. Whilst incidence rates have started to decline across Europe and high-income North America, there are emerging hotspots...Obesity and Urologic cancers: A student’s perspective on risk, systems and surgical implications
During my clinical placements, I began to notice that some patients did not fit neatly into the scenarios we learned about in lectures. One patient in particular had a raised PSA and several comorbidities, including obesity. What stood out was...Functional and reconstructive urology
Case 1 A 45-year-old female presents with a one-year history of urinary leakage, especially worse on coughing. She is otherwise well, with no co-morbidities. What is the International Continence Society (ICS) definition of stress urinary incontinence (SUI)? What are the...MRI screening for prostate cancer: a step towards a ‘prostagram’
The UK National Screening Committee has been calling for further research into alternative screening tests for prostate cancer. The committee decided against prostate cancer screening using prostate specific antigen (PSA) testing on the basis that “PSA is still a poor...BBS Revolution™ Bladder Scanner
Featuring a wireless scanning probe with eight ultrasound transducers for fully automatic bladder detection, BBS Revolution™ differentiates between male/female anatomy, delivering accurate measurements in seconds.
Comparison of PCNL under spinal versus general anaesthesia
There are several advantages of performing percutaneous nephrolithotomy (PCNL) under spinal anaesthesia including lower cost, reduced adverse effects and less tracheal tube displacement. Another advantage is that the patient remains awake throughout making positioning easier and reducing the risk of...How the COVID pandemic has shaped ongoing service delivery at ERIC, The Children’s Bowel & Bladder Charity
- CHARITY FOCUS - Like many organisations and charities, COVID-19 generated a rapid period of adaptation and diversification for ERIC, The Children’s Bowel and Bladder Charity. Their Head of Communications, Alina Lynden, explains what this meant for the organisation and...Use of MRI in the evaluation of prostate cancer: part 1
Introduction Prostate cancer remains the most commonly diagnosed cancer in males and the second leading cause of cancer related deaths in UK men, after lung cancer [1]. The incidence of prostate cancer in the UK has shown a rapid increase...Can the latest patient decision aid help OAB patients?
OAB Answers is a patient decision aid co-authored by several European urologists and gynaecologists, and two patient advocates, to help patients understand and manage their overactive bladder (OAB). It is a 36-page document split into several clear sections, aiming to...Prostate cancer
Case 1 A 65-year-old man is referred to your two-week wait (2WW) clinic with a PSA of 7.0ng/mL. He has no lower urinary tract symptoms (LUTS), no past medical history, no family history of prostate cancer (PCa) and his performance...
