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Potassium citrate in urolithiasis

Kidney stone disease (KSD) is increasing in prevalence globally, with those affected often requiring hospitalisation, diagnostic imaging and intervention [1,2]. The incidences of KSD varies according to several factors including genetics, geographical location, climate, diet and ethnicity [3]. Stone recurrence...

The microbial syndicate: dysbiosis and origins of recurrent UTIs

Traditional dogma held that urine was sterile. However, recent molecular studies have revealed an underground microbial community, known as the urinary microbiome or ‘urobiome’ [1]. Far from being harmful, this community of microorganisms helps modulate immune responses, regulate inflammation, and...

Hypercalciuria in children with monosymptomatic nocturnal enuresis

Nocturnal enuresis, defined as intermittent urinary incontinence, regardless of the presence or absence of daytime symptoms, is common. Monosymptomatic nocturnal enuresis – MSNE (no daytime symptoms) has four main causes identified with it: poor vasopressin action, nocturnal polyuria, poor arousal...

Urethral pain syndrome – is there a light at the end of the tunnel?

Urethral pain syndrome (UPS) is defined in the 2014 EAU Guidelines as the occurrence of chronic or recurrent episodic pain perceived in the urethra, in the absence of proven infection or other obvious local pathology. UPS is often associated with...

A new haemostatic agent in tubeless PCNL

Tubeless percutaneous nephrolithotomy (PCNL) is increasingly being used in carefully selected patients to reduce hospital stay and analgesia requirements, especially in those with little bleeding who become stone free or have insignificant residual fragments (usually <4mm). Various agents have been...

Nocturia – the Cinderella of lower urinary tract symptoms

Nocturia is defined as waking during the night (at least once) to urinate. The important part of the definition relates to the necessity of sleep to precede the episode (although whether sleep must follow the episode is less clear). The...

BCG strain differences have an impact on clinical outcome in bladder cancer immunotherapy

Bacillus Calmette-Guérin (BCG) has been part of the treatment algorithm for non-muscle invasive bladder cancer (NMIBC) for a number of years. In this single centre, prospective, randomised trial, two of the most commonly available strains, BCG Connaught and BCG Tice,...

Horace Powell Winsbury-White: Kiwi, British urologist and Commendatore of the Italian Republic

In this series of articles, I show you some of the exhibits contained in the Museum of Urology, hosted on the BAUS website (www.baus.org.uk). I was recently asked to look into the background of the Winsbury-White Lectures, given biannually at...

Female and functional

Case 1 A 65-year-old woman presents with an 18-month history of “recurrent urinary tract infections” (rUTI). She is otherwise fit and well with no underlying medical problems and no lower urinary tract symptoms. What is the definition of a UTI...

Management of recurrent cystitis

Acute uncomplicated infective cystitis is most commonly seen in healthy women with a frequency of around 0.5-0.7 episodes per woman per year [1]. Around 10% of women report having had an episode of urinary tract infection (UTI) each year and...

Demanding cases or nightmares in endourology? Jan/Feb 2017

In the fifth article in this series the authors describe some of the most complex cases they have encountered. Case 1 A 45-year-old woman was admitted under the care of the medical team with shortness of breath, renal failure and...

Imaging and Intervention in Urinary Tract Infections and Urosepsis

Urinary tract infections (UTIs) are highly prevalent in the community and account for approximately 40% of hospital-acquired infections. Yet, they are often underestimated and under-diagnosed: as one chapter of this book is entitled, nothing is simple about acute pyelonephritis. This...