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Importance of PSA variation – an analysis of PLCO trial data

This study looks specifically at the group of patients in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial (PLCO), to investigate variations in prostate specific antigen (PSA) level. They have specifically included only patients who...

Changing concepts in endourological training – SIMULATE trial

Skill acquisition for endourological procedures is markedly different from traditional open surgical procedures, questioning the applicability of the presently used apprenticeship model. The lack of a universal simulation training curriculum has hampered its adoption into mainstream urological training. This study...

Optimisation of childhood spina bifida management – a prospective trial

Routh et al. describe a prospective trial which aims to determine the optimal urological management for children with spina bifida. The primary aim of neuropathic bladder management is to provide the patient with the best long-term quality of life with...

To clamp or not to clamp – outcomes of the CLOCK trial for robotic partial nephrectomy

The benefits of partial over radical nephrectomy are well established. The CLOCK trial (CLamp vs. Off Clamp the Kidney during robotic partial nephrectomy) was designed as a multicentre, randomised controlled trial to generate evidence on the role of the off-clamp...

The PROMIS trial – time for multi-parametric MRI before a first prostate biopsy

Whilst the relatively random process of 12 core transrectal ultrasound guided (TRUS) prostate biopsy remains by far the most widely employed approach to prostate cancer diagnosis in the UK, its flaws as a standalone diagnostic strategy are increasingly apparent. TRUS-biopsy...

Femeda commence innovative real world clinical trial for Pelviva

A major 330 patient randomised ‘real world’ clinical trial has commenced for Pelviva in conjunction with the University of Manchester and South Manchester GP federation. The trial will compare Pelviva against...

PTNS in overactive bladder

This article will be of interest to those who undertake percutaneous tibial nerve stimulation (PTNS) or are planning to start doing so. This is a computer aided search between 2000-2011 to identify randomised controlled trials (RCT), controlled clinical trials (CCT)...

OAEE UPDATE - Urgent Call for Surgical Supplies in Ukraine

UK professionals have called for aid in sending surgical equipment to Ukraine during Russian invasion.

Comparing intravesical chemohyperthermia with Mitomycin C versus BCG in treating bladder cancer

In the advent of the recent Bacillus Calmette–Guérin (BCG) crisis, the importance of alternative adjuvant treatments for intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC) has been highlighted. Chemohyperthermia (CHT) has emerged as an option, however there remains a lack of...

Onabotulinum toxin A (BTX) not helpful for chronic scrotal pain

It is refreshing to read a report on negative outcomes as it reinforces the honesty that is often lacking with the well-known publication bias in medical publications. It is also not common to come across surgical randomised controlled trials (RCTs)...

SIU Academy Bench to Bedside

This event was submitted to the European Accreditation Council for Continuing Medical Education (EACCME) and is awaiting CME approval. SIU ACADEMY BENCH TO BEDSIDE URO-ONCOLOGY GU CANCER TRIAD 7 November 0800-1130 AM EST – Bladder & Kidney Cancers 8 November...

Reviewing the evidence for TNS in neurogenic lower urinary tract dysfunction

Tibial nerve stimulation (TNS) is a recognised minimally invasive treatment option for bladder overactivity and non-neurogenic lower urinary tract dysfunction. In this systematic review, the role TNS can play in the management of neurogenic lower urinary tract dysfunction is evaluated...