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PARP inhibitors and prostate cancer
The discovery that BRCA1/2-deficient tumour cells are highly sensitive to poly-ADP ribose polymerase (PARP) inhibitors (PARPi) established the foundation of synthetic lethality in metastatic castration-resistant prostate cancer (mCRPC). The TOPARP-A trial confirmed clinical benefit, with PARPi activity largely restricted to...Urinary tract stones
Case 1 What does this plain X-ray of kidneys, ureters and bladder (KUB) show? What, according to the 2009 The National Institute for Health and Care Excellence (NICE) guidelines, is the most appropriate first-line treatment? What factors do the NICE...Improving on the Rotterdam Prostate Cancer Risk Calculator
Following the PROMIS trial [1], many cancer centres in the UK are now offering pre-biopsy multiparametric MRI (mpMRI) for men suitable for radical treatment. The European Association of Urology for Prostate Cancer (PCa) guidelines recommend individual risk stratification before the...Technology for remote working and COVID-19 resources
The COVID-19 pandemic has altered every aspect of how we live, and how healthcare needs to be provided for the welfare of patients and staff. I thought I would try to summarise a few potential technology tools that could be...Stone Pass: Kidney Stones app
For this Digital Review I have focused on the Stone Pass: Kidney Stones app (Know Stone LLC) – a new information tool for patients with ureteric stones. I had recently seen a shared tweet originating from the app’s author Dr...Preparing for the FRCS (Urol) viva
Ping! You look down to your phone and you have just received an email saying, “Congratulations, you have now successfully completed The Joint Committee on Intercollegiate Examinations section 1 of the Fellowship of the Royal College of Surgeons (Urol) exam.”...Metabolic stone disease for urology trainees
Urolithiasis continues to be a heavy burden on the worldwide medical infrastructure with an estimated 106 million cases recorded internationally in 2021 [1]. Whilst incidence rates have started to decline across Europe and high-income North America, there are emerging hotspots...In conversation with Professor Christopher Chapple
Professor Christopher Chappel. Prof Chapple, thank you for taking the time to chat with the Urology News team. Can we start by asking about your background and how you ended up in the field of urology? Early in my career...Renal masses
Case 1 A 70-year-old female presented under the medical team with malaise, weight loss, and deranged liver function tests (LFTs) and calcium (ALP 350, GGT 650, Serum bilirubin 29, normal aminotransferases, Ca 3.3). An abdominal ultrasound scan (USS) was performed...The importance of active investigation and follow-up in bladder injury
Bladder injury (BI) is uncommon, and patients are typically managed by large multidisciplinary teams, dealing concomitantly with other injuries or diagnoses. BI can be categorised by cause (traumatic vs. iatrogenic) or anatomical location (intraperitoneal vs. extraperitoneal), requiring differing approaches to...Urolithiasis 2 – extracorporeal shockwave lithotripsy
- Click for Part 1 and Part 3 on this topic - Case scenario A 37-year-old male presents to A&E with 12 hours of intermittent, severe, left-sided loin to groin pain and multiple episodes of vomiting. Urine dipstick shows 2+...
