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Clinical trials 1

Clinical Trials 2 is available here. Case 1 1. What are the levels of clinical evidence based on the 2009 definitions from the ‘Oxford CEBM’? 2. What is the null hypothesis? 3. What are type 1 and type 2 errors?...

Rocks of ages

In this series of articles, I am going to show you some of the exhibits contained in the Museum of Urology, hosted on the BAUS website (www.baus.org.uk). During a recent junior doctors’ strike, whilst I was re-living my houseman days...

Solifenacin for children and adolescents with overactive bladders

Solifenacin (VESIcare®) is the second-line anti-muscarinic medication of choice for my patients with overactive bladder (oxybutynin being my initial choice). However, currently, it remains unlicensed for use in children. Newgreen et al. have evaluated the long-term safety and efficacy of...

Urethral sphincter function before and after radical prostatectomy

This paper from Holland will be useful for urologists involved in radical prostatectomy (RP) for cancer of the prostate. It presents a PubMed search between 1980 and 2012. Twenty-five out of 124 articles were further analysed, mainly English-language papers. Several...

Retention after Botox therapy in OAB

Treatment of overactive bladder (OAB) has a wide spectrum. The first step is lifestyle modifications, the second step is pharmacotherapy and the third line is intradetrusor injections with Botox®. This retrospective study is from Tennessee, USA in non-neurogenic and refractory...

Oestrogens and OAB

This is a multicentre study from Europe. The female genitals and lower urinary tract have a common embryological origin arising from urogenital sinus. Therefore, both could be sensitive to female sex steroid hormones. Oestrogens and progesterone receptors have been demonstrated...

New therapy for overactive bladder

Overactive bladder (OAB) is a complex symptom that can adversely affect quality of life. So far pharmacotherapy has focused on anti-cholinergic drugs. Recently, beta-adrenoreceptors have been identified as having an effect on the detrusor muscle and urothelium. Beta-3 is the...

TUF Warriors – joining the fundraising fight

What is the TUF Warrior programme? The Urology Foundation (TUF) Warrior programme is designed to support core trainees, clinical fellows and foundation doctors interested in urology. It creates opportunities to develop extracurricular interests, connect with patients, boost applications for specialty...

Together for 35 years: leading change in paediatric bowel and bladder health.

ERIC, The Children’s Bowel & Bladder Charity, returns with its biennial conference. This is a key event for healthcare professionals featuring cutting-edge research, interactive workshops, practical demonstrations and much more. Around 1 in 9 children and young people in the...

STIMVIA Appoints Award-Winning CEO Russ Mably to Accelerate Global Growth and Advance Personalised Neuromodulation

STIMVIA, a neuromodulation company focused on transforming the treatment of bladder dysfunction, today announced the appointment of Russ Mably as Chief Executive Officer. Mably will lead the company through its next phase of international growth, expanding access to STIMVIA's personalised...

Paediatric urology – peno-scrotal

Case 1 A four-year-old boy presents to clinic following GP referral unable to retract the foreskin (Figure 1). Figure 1. What is the diagnosis? The above condition may be pathological or physiological; clinically how can you differentiate this? Explain the...

Tackling stones in children: is it difficult to crack on?

The incidence of stone disease in the paediatric population has been increasing worldwide, particularly for the adolescent age group (12–17 years of age). In this article the authors discussed the evolutions of percutaneous nephrolithotomy (PCNL) and ureteroscopy (URS) in children....