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Anti-VEGF and PD-1 combinations in renal cell carcinoma

Over the past decade, vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors (TKIs) have been central to treating renal cell carcinoma (RCC), with oncologists refining dosing strategies to balance treatment efficacy with quality of life (QoL). Recently, the introduction of...

Penile augmentation using injectable filler

Penile size is a major topic for many men and a source of anxiety throughout history. The common belief that a large penis is necessary to impress and satisfy their sexual partners has led to the notion that ‘bigger is...

An algorithm for the management of haemorrhagic cystitis

Haemorrhagic cystitis (HC) can be one of the most difficult conditions to treat in urological practice. It is characterised by intractable bleeding from the bladder and may be acute or chronic. The most frequently reported causal factors are radiotherapy (RT)...

Updated guide on integrated paediatric continence services to significantly improve children’s lives and save NHS cost

The Paediatric Continence Forum has recently launched its updated Guide on how to commission and run integrated, nurse-led, community-based paediatric bladder and bowel (continence) services. These are clinically effective, improve the lives of children and their families and generate significant...

Retroperitoneal sepsis

Case 1 An 80-year-old woman presented with history of recurrent and recent cystitis, low grade pyrexia, abdominal and back pain, and pain on movement of the left hip which was observed to be flexed and externally rotated. What is the...

Do not hesitate and start using the hashtag, #UroSoMe!

In recent years, the digitisation of scientific information has been astonishing and the use of social networks has been increasing worldwide. Social networks play a fundamental role in the dissemination of information and scientific knowledge in the field of urology...

Optimisation of childhood spina bifida management – a prospective trial

Routh et al. describe a prospective trial which aims to determine the optimal urological management for children with spina bifida. The primary aim of neuropathic bladder management is to provide the patient with the best long-term quality of life with...

All biochemical recurrences are equal, but some are more equal than others

Despite significant technological advancements, radical prostatectomy (RP) and radiotherapy (RT) are not always effective in curing localised prostate cancer (PCa). Many patients experience a rise in prostate-specific antigen (PSA), known as biochemical recurrence (BCR), leading to considerable anxiety and a...

New distributor appointed for Urethrotech UCD

Urethrotech® Ltd., who develop innovative solutions for safe lower urinary tract instrumentation, have appointed Pennine Healthcare as their exclusive distributor in the United Kingdom and the Republic of Ireland.

Association of prostate size with capsule thickness and glandular epithelial cell density

Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are two significant urologic diseases affecting ageing men. BPH is histologically evident in over half of men above 50, while PCa is a highly lethal cancer prevalent in men in the United...

Urology around the world: India: past, present, and future

Past India has the largest population in the world, standing at 1.43 billion as of September 2023. This vast population across a huge geographical area brings unique healthcare challenges, including the full range of urologic conditions. Urology is a relatively...

Intravesical GAG replacement therapies for bladder pain syndrome / interstitial cystitis – an update

The barrier function of the glycosaminoglycan (GAG) layer of the urothelium was identified by Parsons in 1975, and intravesical therapies to treat chronic inflammatory conditions of the bladder were developed soon after. However, the active role of the urothelium in...