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What is the role of evidence-based medicine in urology?
The concept of ‘evidence-based medicine’ (EBM) was first developed in the early 1990s and was described as “the conscientious, explicit and judicious use of the current best evidence in making decisions about the care of individual patients” by the recently...
Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer
Abiraterone acetate, the prodrug of abiraterone, blocks endogenous androgen synthesis by inhibiting cytochrome p-450c17, a critical enzyme in androgen biosynthesis. Its active D4A metabolite also has anti-tumour effects through possibly multiple mechanisms. 3-5% of men diagnosed with prostate cancer in...
Long-term complications of bulking agents in the treatment of SUI
Incontinence poses a substantial economic burden on the UK’s NHS, estimated at £536 million in 1999/2000, equivalent to approximately 1.1% of the total NHS spend, for both men and women. Over two decades later, this cost is expected to have...Frailty in urology – part 2
The first article in this series defined frailty and introduced the concept and importance of identifying patients living with frailty who undergo surgery, including those undergoing urological procedures. In the second part of this series we outline how to identify...Fournier’s gangrene
Introduction Fournier’s gangrene (FG) is a rare but fulminant form of infective necrotising fasciitis affecting the perineum and external genitalia, which can rapidly progress along fascial planes. It most commonly affects men, but can occur in women and children, with...
Telemedicine – safe, convenient and economical
I am sure that most, if not all, readers of Urology News will have utilised some form of telemedicine over the last few months during the height of the COVID-19 pandemic. This timely publication from Boston Children’s Hospital precedes the...
Does maternal exposure during pregnancy to higher ambient temperature increase the risk of hypospadias?
The search for the causes of hypospadias continues at a pace. These authors from Turkey extrapolated other findings about the higher incidence of congenital anomalies in babies during summer months’ gestation to studying the risks of high ambient temperature during...The transition from surgeon to manager during the COVID-19 response
Writing this article on the first Sunday in May, when in any other year, I would be wearing my bowler hat in Hyde Park for the annual Cavalry Memorial Parade, a time ‘pre-COVID’ does seem a very distant memory. Having...NICE has recently moved the IRE guidelines from ‘Research Only’ to ‘Special Arrangements’
This recent update provides increased access to the AngioDynamics NanoKnife IRE ablation...The adrenals
Case 1 A 45-year-old man undergoes a CT of his abdomen to stage a newly diagnosed bowel malignancy. What does the scan show? What findings on a CT scan suggest an adrenal lesion is benign? If the CT scan is...
