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Update on immunotherapy for non-muscle invasive transitional cell carcinoma of the bladder
Patients with high-risk non-muscle invasive bladder cancer (NMIBC) that have failed Bacillus Calmette-Guérin (BCG) treatment are a difficult group to treat, and many may not be suitable for the preferred treatment option of radical cystectomy. Bladder-preserving treatments for BCG-unresponsive high-risk...
Antimuscarinics and behaviour in patients with spinal dysraphism
Since the 1980s patients with spinal dysraphism have had aggressive bladder management with clean intermittent catheterisation and anticholinergic therapy from early on in life. This strategy aims at improving lower and therefore upper urinary tract function thus decreasing the risk...Male infertility
Definitions Infertility is the inability of a sexually active, non-contracepting couple to achieve spontaneous pregnancy in one year [1]. About 15% of couples do not achieve pregnancy within one year and seek medical treatment for infertility. Semen parameters are standardised...Kidney stones in pregnancy
Urolithiasis related complications are estimated to affect between 1:200 and 1:2000 pregnancies [1,2]. With around 825,000 conceptions in England and Wales in 2021 [3], this represents an uncommon but not rare occurrence. What is normally a straightforward pathway for a...The role of PET-CT imaging in prostate cancer
Prostate cancer (PCa) is the second most common cancer in the UK, with 43,000 cases in 2017-18 [1,2]. Accurate primary staging and the detection of suspected recurrence following treatment is vital for directing management and predicting prognosis. This has conventionally...EBM Stats Calc: there’s a stat for that
Quantifying the value of a specific test or intervention for a patient is no easy feat. Even when the value of a given test or intervention has been established, there may be additional case-specific factors to consider that are not...
When partial nephrectomy is unsuccessful
With increasing use of partial nephrectomy (PN) to treat complex T1 tumours, the risk of conversion to radical nephrectomy (RN) increases. In this study the authors look at the incidence of conversion of robotic PN (RPN) to RN and analysed...
Which is better – laparoscopic or open paediatric pyeloplasty?
In an attempt to answer the above question, Gatti et al. undertook a randomised controlled trial between 2005 and 2014. All children aged 1 to 18 years of age requiring surgery for pelviureteric junction (PUJ) obstruction were enrolled. A total...
