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Radium-223 treatment outcomes after multiple lines of mCRPC therapy in clinical practice: implication of pre-treatment spinal epidural disease
There are a number of treatments now available to patients with metastatic castrate-resistant prostate cancer (mCRPC). However, the optimal timing and order in which they are given is less clear. Radium-223 was FDA-approved for mCRPC patients with symptomatic bone metastases...
Prognostic impact of preoperative neutrophil-to-lymphocyte ratio after radical prostatectomy
Neutrophil-to-lymphocyte ratio has been shown to be a prognostic factor in a number of different cancers. This is one of the largest studies to date to evaluate its effect on overall survival in patients who have undergone radical prostatectomy (RP)...
Predictors of vaginal mesh exposure after mid-urethral sling placement
Vaginal mesh exposure following mid-urethral sling (MUS) insertion can be a difficult complication to treat. The aim of this study was to identify possible risk factors in patients who had unfortunately developed vaginal mesh exposure following MUS surgery. This was...
Comparison of the microbiological milieu of CIC patients
Children performing clean intermittent catheterisation (CIC) have a higher risk of bacteriuria. This occasionally can lead to full urinary tract infection (UTI) which can influence long-term renal function. Hydrophilic catheters are said to be less traumatic to the urothelium and...
Should maximal urethral closure pressure be performed before mid-urethral sling surgery for stress incontinence?
Maximum urethral closure pressure (MUCP) is a means of trying to provide an objective assessment of urethral integrity. In some centres it is used as a tool to help predict outcomes after mid-urethral sling (MUS) placement. The authors propose that...
Outcome analysis of paediatric pyeloplasty
This prospective study from India included 744 patients of whom 112 had renal function less than or equal to 20% at the time of diagnosis. Thirty percent underwent a nephrostomy initially. Ten with no function had a nephrectomy. Of the...
Sepsis and antibiotics: the debate goes on
Sepsis statistics are staggering around the world. The UK Sepsis Trust estimates that there are around 150,000 cases of sepsis in the UK every year and it kills 44,000 patients per year. There are many different definitions and criteria; in...
Do complementary therapies work in painful bladder syndrome?
The aim of this systematic review was to evaluate the effectiveness of complementary therapies in the treatment of bladder pain syndrome. An electronic search identified 1454 articles; however, after review by two independent reviewers, this was reduced to 11 articles...
Surgical management of urethral diverticula in women
This systematic review aimed to evaluate different surgical techniques and their outcomes used for treating women with urethral diverticulae. One hundred and eight studies were identified; some of these however were single case reports (37%). As one would expect the...
Predicting bone scan positivity in non-metastatic CRPC
There is evidence that suggests that early treatment with chemotherapy, immunotherapy or hormone therapy leads to a better response in patients with asymptomatic metastatic castrate resistant prostate cancer (CRPC). This study aimed to predict bone scan positivity in patients with...
Rectal swab testing before prostate biopsy
This study explored the real terms value of rectal swab testing and targeted antibiotic prophylaxis in patients undergoing transrectal ultrasound prostate biopsy in view of increasing bacterial resistance to fluoroquinolones (17.6% in North America, 40% in Hong Kong). The authors...
