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COVID-19 and acute kidney injury

7 July 2020 | | URO - Covid-19, URO - Trauma & Emergency
Newspapers and online media are full of the effects of the coronavirus on airways and olfactory functions and the importance of respiratory physicians (pulmonologists in the USA), ventilators and intensive care teams. However, as per the Intensive Care National Audit...
BJUI International journal cover image.

BCG after TURBT – does timing matter?

2 March 2022 | | URO - Urologic Oncology
Intravesical bacille Calmette–Guerin (BCG) therapy continues to be widely used for patients with intermediate / high-risk non-muscle invasive bladder cancer (NMIBC). In this article, the researchers identified the lack of sufficient evidence with regards to timing of BCG after transurethral...

MRI targeted transperineal prostate biopsy: a local anaesthetic approach

1 March 2018 | | URO - Urologic Oncology
Transperineal template biopsy remains the gold standard investigation in diagnosis of prostate cancer. Data from the PROMIS study demonstrated the low sensitivity of transrectal ultrasound (TRUS) biopsy as a diagnostic tool, and highlighted the need for a better diagnostic pathway....

TPTNS: evaluation of a therapeutic option in the management of anticholinergic refractory overactive bladder

1 March 2015 | | URO - Functional / Reconstructive Urology
This is a prospective study evaluating the tolerability and efficacy of transcutaneous posterior tibial nerve stimulation (TPTNS) in patients with urodynamically proven overactive bladder (OAB), who have failed anticholinergic treatment. Forty-three patients were studied and followed up over a period...

A phase II dose-ranging study of mirabegron in patients with OAB

1 March 2014 | | URO - Functional / Reconstructive Urology
This was a multinational, multicentre, randomised, double–blind, double-dummy, parallel group placebo- and active- controlled phase II study. The study enrolled 1108 men and women aged 18 and over. The criteria were: patients must have had overactive blader (OAB) symptoms for...

Solifenacin and mirabegron are safe and effective in combination

1 September 2015 | | URO - Functional / Reconstructive Urology
Antimuscarinic agents remain the mainstay of medical management of bladder overactivity. Limited somewhat by their tolerability, the new agent mirabegron, a β3-adrenoreceptor agonist, has been approved as an alternative. There is little known however about the possible synergistic effects of...

Clear cell urothelial carcinoma: a highly aggressive morphological variant in the bladder and upper urinary tract

2 November 2023 | | URO - Urologic Oncology
Clear cell urothelial carcinoma (CCUC) is a rare morphological variant of transitional cell carcinoma (TCC). It can occur anywhere along the urothelial tract and is characterised histologically by high grade carcinoma with an abundance of clear, glycogen-rich cytoplasm [1]. Alternative...

The assessment and medical treatment of LUTS secondary to BPH

1 November 2016 | URO - Functional / Reconstructive Urology
The term benign prostatic hyperplasia (BPH) describes prostate enlargement due to non-cancerous processes. Several aetiological mechanisms are involved, including hormonal and vascular alterations; abnormal regulation of apoptosis; and prostatic inflammation, which may stimulate cellular proliferation. With ageing, prostate enlargement can...

Read all about it Sep/Oct 2019

1 September 2019 | URO - Functional / Reconstructive Urology, URO - Urologic Oncology
It can be awkward when a patient asks you about a report in their favourite tabloid detailing an amazing research breakthrough or a ‘cutting-edge’ new treatment / test and you don’t know what they are talking about! So this section...

Retroperitoneal fibrosis

1 September 2017 | | URO - Endourology & Stones, URO - Uroradiology
Introduction Retroperitoneal fibrosis (RPF) is a condition that occurs when extensive fibrosis develops in the retroperitoneum, usually centred over the anterior aspect of the fourth and fifth lumbar vertebrae. The fibrotic tissue typically surrounds the infrarenal aorta, inferior vena cava...

Demanding cases or nightmares in uro-oncology? Jan/Feb 2023

6 January 2023 | | URO - Urologic Oncology
Radical surgical treatment of prostate cancer has become minimally invasive owing to robotic assisted laparoscopic technology [1]. Patients who undergo robotic assisted radical prostatectomy (RARP) often have lower risk of morbidity compared to an open approach. However, patients with a...

Medical statistics for urologists: part 2 – probability and hypothesis testing

2 March 2022 |
Following on from Part 1 of this series (Part 3 available here), this article aims to build on other analytical techniques commonly used within medical research, focusing on simple examples. Probability and testing Before exploring hypothesis testing, it is vital...