You searched for "PCa"
Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer
Abiraterone acetate, the prodrug of abiraterone, blocks endogenous androgen synthesis by inhibiting cytochrome p-450c17, a critical enzyme in androgen biosynthesis. Its active D4A metabolite also has anti-tumour effects through possibly multiple mechanisms. 3-5% of men diagnosed with prostate cancer in...
Characteristics of APC and the usefulness of MP-MRI for diagnosis
The authors evaluated the pathological and oncological characteristics of anteriorly located prostate cancer (APC) in 728 RP specimens, and the accuracy of multiparametric magnetic resonance imaging (MP-MRI) for APC evaluation. Patients were characterised as APC (70% or more of tumour...
Patients’ preferences for additional (cytoreductive) treatments to the prostate and metastasis in metastatic prostate cancer
Patients diagnosed with metastatic prostate cancer at first diagnosis or de novo synchronous metastatic hormone-sensitive prostate cancer (mHSPC) have had reported increases in overall survival due to rapid advances and intensification of systemic therapy regimes beyond traditional androgen deprivation therapy...An update on antibiotic prophylaxis in TRUS-guided prostate biopsy
Since its inception in the 1980s, transrectal ultrasound (TRUS)-guided prostate biopsy has remained the standard tool for the histological diagnosis of prostate cancer. There are several advantages to this technique which have led to the widespread use of TRUS in...Andrology (2020)
Case 1 What is the diagnosis based on the blood test, and how is the diagnosis made? What additional blood tests are required? What are the clinical manifestations of this? What are the options / modes of delivery for treatment?...In conversation with Jane Brocksom
We were delighted to chat to Jane Brocksom, President of BAUN, about her background in urology nursing and plans for the association in its 25th year. Can you tell us a bit about your background and what led you into...Post radical nephrectomy presenting with skull metastasis
We present the case of an 83-year-old female who underwent right radical nephrectomy for renal cell carcinoma (RCC). Despite negative surgical margins, the patient presented with a skull metastasis six years post radical nephrectomy. This case highlights the importance of...Going for Gold… and Girth: Olympic rumours, and the new BAUS consensus on penile augmentation
The Winter Olympics are a bewildering spectacle at the best of times, particularly for causal quadrennial viewers of alpine sports such as myself. Personal highlights of this year’s iteration in Milano-Cortina included the superhuman performance of the Norwegian Johannes Klaebo...HIV / AIDS – implications for the urologist
“It’s no fun to have HIV even though it’s viewed as a chronic, controllable disease. It means being wedded to the health system.” - Philip Berger, Associate Professor in the Department of Family and Community Medicine, Toronto, Canada; and leading...Recent advances in the management of castration resistant prostate cancer
Castrate resistant prostate cancer (CRPC) is defined by disease progression despite androgen-deprivation therapy lowering testosterone to castrate levels. It may present as a rise in serum levels of prostate specific antigen (PSA), progression of pre-existing disease, or the appearance of...Use of MRI in the evaluation of prostate cancer: part 1
Introduction Prostate cancer remains the most commonly diagnosed cancer in males and the second leading cause of cancer related deaths in UK men, after lung cancer [1]. The incidence of prostate cancer in the UK has shown a rapid increase...
