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The potential of statin use in castrate resistant prostate cancer treatment

1 May 2016 | | URO - Urologic Oncology
One of the mechanisms by which prostate cancer achieves castrate resistance is through de novo intratumoral production of androgens. Reactivation of androgen receptors results in promotion of cell survival and proliferation pathways despite castrate serum testosterone levels. As androgen synthesis...

What’s new in post prostatectomy incontinence?

1 January 2017 | | URO - Functional / Reconstructive Urology
With an ageing population, the number of men being diagnosed with prostate cancer each year is steadily rising. With more specific investigations, such as multiparametric magnetic resonance imaging (MpMRI) and transperineal biopsies, the number of cases diagnosed at an earlier...

Bladder urothelial neoplasms in children

1 January 2016 | | URO - Paediatric Urology
Urothelial bladder neoplasms are rare in children, occurring in 0.1-0.4% of the population before the age of 20. There are no current paediatric guidelines to their management. This study retrospectively reviews the files of patients from three tertiary centres between...

Thiazide diuretic prophylaxis for kidney stones and the risk of diabetes mellitus

1 May 2015 | | URO - Endourology & Stones
Thiazide diuretics have been used to reduce calcium nephrolithiasis recurrence as it is tolerated well, inexpensive and reduces calcium excretion in urine. It has been linked with increased risk of diabetes mellitus (DM) in the presence of hypertension (ALLHAT study),...

Medical Protection: Expertise, advocacy, and support when it matters most

21 August 2025 | Company Profiles
The world’s leading medical defence organisation providing long-term protection against the potentially ruinous costs of litigation, as well as the other professional challenges that healthcare professionals might face during the course of their career. As a doctor your work is...

The expanding indications for ureteroscopy – ad maiora!

1 March 2019 | | URO - Endourology & Stones, URO - Paediatric Urology, URO - Technology
The management of urolithiasis is becoming a Herculean task for healthcare providers worldwide. The incidence of stone disease is rising, with predicted lifetime risk of 12% in males and 6% in females [1]. This rise relates to both improving imaging...

The burning issue of urinary tract infections

1 September 2018 | | URO - Infection, URO - Functional / Reconstructive Urology
Urinary tract infections (UTIs) occur when bacteria colonise and proliferate in the urinary tract. These are characterised by specific clinical symptoms (dysuria, suprapubic tenderness, urgency and urinary frequency) which commonly occur alongside the finding of bacteriuria. UTIs are common –...

Prostate cancer in men of African heritage: understanding the risk and prognostic factors

2 July 2025 | | URO - Urologic Oncology
Prostate cancer (PCa) represents a major public health concern and is recognised as one of the most common cancers worldwide, accounting for a significant proportion of cancer-related deaths. It is the second most common malignancy among men globally after lung...

Nocturnal enuresis in children

1 May 2017 | | URO - Functional / Reconstructive Urology, URO - Paediatric Urology
Introduction Nocturnal enuresis is the complaint of bedwetting. The 2010 National Institute for Health & Care Excellence (NICE) guidelines define bedwetting as the “involuntary wetting during sleep without any inherent suggestion of frequency of bedwetting or pathophysiology” [1]. Bedwetting is...

ICS updates in continence care: the role of the nurse continence specialist in continence services

1 November 2016 | | URO - Functional / Reconstructive Urology
The nurse who specialises in continence care is recognised as a key member of interdisciplinary teams seeking to deliver high quality integrated continence services. The recently published international service specifications for continence care [1] supports the use of specialist continence...

Purple urine bag syndrome

1 July 2021 | | URO - Infection, URO - Functional / Reconstructive Urology, URO - Trauma & Emergency
Purple urine bag syndrome (PUBS) is an uncommon phenomenon where the tubing and urinary catheter bag is noticed to undergo purple discolouration. This has been linked with urinary tract infections (UTI), chronic debilitated states and prolonged catheterisation. PUBS was noticed...

Ketamine uropathy – an update

29 January 2020 | | URO - Functional / Reconstructive Urology
The first two case series that documented the association between urinary tract damage and recreational ketamine use were published 12 years ago [1,2]. Since then ketamine has maintained a controversial profile as an essential medication of expanding utility but with...