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European Urology journal front cover.

Tissue-based biomarkers steering clinical decisions in patients with urothelial cancer

2 July 2025 | | URO - Urologic Oncology
Biomarkers play an essential role in the diagnosis and treatment of urothelial cancer (UC), with PD-L1, FGFR, and MMR proteins being the most clinically established. These biomarkers, derived from histological specimens, guide therapeutic decisions for bladder cancer (BCa) and upper...

In conversation with Professor Christopher Chapple

1 March 2017 | URO - Core Urology
Professor Christopher Chappel. Prof Chapple, thank you for taking the time to chat with the Urology News team. Can we start by asking about your background and how you ended up in the field of urology? Early in my career...

Sexually transmitted infections

1 May 2018 | URO - Infection, URO - Trauma & Emergency
Case 1 A 27-year-old man presents to the clinic with multiple asymptomatic penile lesions. 1. What is the diagnosis? 2. What are the likely pathogens which cause these lesions? 3. What treatment options are available to treat these lesions? 4....

History of prostate biopsy – part 2

1 September 2018 | | URO - Basic Science Research, URO - Urologic Oncology, URO - Technology
For Part 1 of this topic is available here. The major limitations of the transrectal ultrasound (TRUS) guided prostate biopsy (PBx) protocols are the risk of profound sepsis and the risk of persistently significant false negative rates, related to the...

The process of medical innovation – evolving trends and future perspectives

5 May 2021 | | URO - Technology
In 2018 the United Kingdom Government spending on healthcare totalled almost £166 billion. Of this approximately 65% was attributed to providing curative or rehabilitation therapy, with health-related long-term care and provision of goods accounting for 25%. The remaining was accredited...

Urologic complications of radiotherapy

1 July 2014 | | URO - Urologic Oncology
Case 1 1. What machine is seen in the picture? 2. What is the standard dose schedule for radiotherapy for prostate cancer? 3. What are the complications of radiotherapy? Case 2 1. How does haemorrhagic cystitis develop? 2. What are...

Image-guided renal cryoablation

1 November 2014 | | URO - Urologic Oncology, URO - Uroradiology
Introduction There has undoubtedly been a dramatic increase in the number of patients diagnosed with small renal masses in recent years [1]. The rapidly expanding use of CT has led to a large number of incidental diagnoses, but increasing longevity...

Bladder cancer: where are we with intravesical therapies?

1 July 2016 | | URO - Urologic Oncology
In the United Kingdom, almost 10,500 new cases of bladder cancer were identified in 2013, with over 5000 deaths in 2012 [1]. Seventy percent of new cases will be non-muscle invasive bladder cancer (NMIBC) at diagnosis and therefore will be...

Renal masses

2 March 2022 | | URO - Urologic Oncology
Case 1 A 70-year-old female presented under the medical team with malaise, weight loss, and deranged liver function tests (LFTs) and calcium (ALP 350, GGT 650, Serum bilirubin 29, normal aminotransferases, Ca 3.3). An abdominal ultrasound scan (USS) was performed...

Neuroendocrine bladder tumour

5 February 2025 | | URO - Urologic Oncology
A 75-year-old male with a history of prostate adenocarcinoma (T3b/T4 N1 M1b, Gleason 4+3) on Zoladex® and enzalutamide, presented with visible haematuria. His prostate specific antigen (PSA) had decreased from 43.6ug/L in December 2022 to 0.02ug/L. He also had a...

Bladder cancer

5 November 2019 | URO - Urologic Oncology
Case 1 A 78-year-old female presents with a week history of painless haematuria. She’s a smoker and used to work in the textiles industry. She underwent a flexible cystoscopy. What does this image show? What are the two-week wait National...

Feeling like a fraud — imposter syndrome: what it is and what to do about it

17 April 2024 | | URO - Core Urology
Have you ever been plagued by feelings of incompetence despite evidence to the contrary, then this article is for you. Dr Dunay Schmulian provides insight into imposter syndrome and what to do about it. Excerpt 1 Consultant:That was excellent, and...