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Bladder cancer – an overshadowed ‘volcano’

1 May 2015 | | URO - Urologic Oncology
Bladder cancer has often been overshadowed by the limelight of prostate cancer. However, of all the urological cancers, bladder cancer is the only one which has shown a slight decline in age-standardised five-year survival rates over the last couple of...

Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer

1 July 2017 | | URO - Urologic Oncology
Abiraterone acetate, the prodrug of abiraterone, blocks endogenous androgen synthesis by inhibiting cytochrome p-450c17, a critical enzyme in androgen biosynthesis. Its active D4A metabolite also has anti-tumour effects through possibly multiple mechanisms. 3-5% of men diagnosed with prostate cancer in...

The NICE Guideline on Urinary Incontinence: the management of urinary incontinence in women

1 May 2014 | | URO - Functional / Reconstructive Urology
Background Urinary incontinence (UI) is a common symptom that can affect women of all ages. It is difficult to estimate the prevalence of UI since it is often under-reported, although the Norwegian EPINCONT study looking at women over 20 reported...

Inpatient care of patients with established spinal cord injury - what a general urologist needs to know

1 January 2014 | | URO - Trauma & Emergency, URO - Neurourology
Introduction Spinal cord injury (SCI) is a devastating, life-changing condition, which is currently irreversible. Depending on the level of the spinal cord affected (and whether the lesion is complete or incomplete), patients may subsequently develop reduced voluntary motor function, sensory...

Prostate cancer management 2 – metastatic disease

2 July 2025 | | URO - Urologic Oncology, URO - Core Urology, URO - Uroradiology
A 72-year-old gentleman is referred to you in the two-week wait clinic with a prostate specific antigen (PSA) of 22ug/L. He is otherwise fit and well and does not take any regular medication. His multi-parametric magnetic resonance imaging (mpMRI) shows...

Spencer Wells

1 March 2016 | | URO - Technology
In this series of articles I am going to show you some of the exhibits contained in the Museum of Urology, hosted on the BAUS website (www.baus.org.uk). In the last article I wrote about some well-used eponyms seen in the...

Intravesical GAG replacement therapies for bladder pain syndrome / interstitial cystitis – an update

4 May 2020 | | URO - Functional / Reconstructive Urology, URO - Infection, URO - Basic Science Research
The barrier function of the glycosaminoglycan (GAG) layer of the urothelium was identified by Parsons in 1975, and intravesical therapies to treat chronic inflammatory conditions of the bladder were developed soon after. However, the active role of the urothelium in...

The role of PET-CT imaging in prostate cancer

4 October 2021 | | URO - Urologic Oncology
Prostate cancer (PCa) is the second most common cancer in the UK, with 43,000 cases in 2017-18 [1,2]. Accurate primary staging and the detection of suspected recurrence following treatment is vital for directing management and predicting prognosis. This has conventionally...

Nocturnal enuresis in children

1 May 2017 | | URO - Functional / Reconstructive Urology, URO - Paediatric Urology
Introduction Nocturnal enuresis is the complaint of bedwetting. The 2010 National Institute for Health & Care Excellence (NICE) guidelines define bedwetting as the “involuntary wetting during sleep without any inherent suggestion of frequency of bedwetting or pathophysiology” [1]. Bedwetting is...

A Core Trainee’s Guide to Preparing for a Career in Urology

1 March 2014 | | URO - Core Urology
National Selection pits the best of the UK’s core surgical trainees (sorry – that includes EEC countries as well) against each other in a process that determines who is allowed to proceed into higher surgical training. For the successful, it...

Use of Clavien-Dindo classification in urology part 1 – pelvic surgery

1 March 2016 | | URO - Urologic Oncology
There is no widely accepted system to classify postoperative complications. It is necessary to compare the outcome and complications while validating a new surgical procedure or one of the surgical approaches of a particular condition. Several parameters have long been...

Molecular biology – bladder cancer

1 January 2014 | | URO - Basic Science Research, URO - Urologic Oncology
Background Bladder cancer is the most common cancer of the urinary tract and approximately 90% of bladder cancers diagnosed in North America and Europe are transitional cell carcinomas (TCC). For the purposes of diagnosis and treatment, bladder cancer is often...