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Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer

1 July 2017 | | URO - Urologic Oncology
Abiraterone acetate, the prodrug of abiraterone, blocks endogenous androgen synthesis by inhibiting cytochrome p-450c17, a critical enzyme in androgen biosynthesis. Its active D4A metabolite also has anti-tumour effects through possibly multiple mechanisms. 3-5% of men diagnosed with prostate cancer in...

Medical statistics for urologists: part 1

3 September 2021 |
Part 2 of this article is available here, and Part 3 here Clinicians often consider statistics to be a dry and challenging subject. However, an understanding of the basics of statistic methods underpins the interpretation and use of current best...

Virtual and augmented reality in surgery

1 January 2018 | | URO - Technology
Virtual reality (VR) is a three-dimensional, computer generated environment which can be accessed using a virtual reality headset, allowing individuals to immerse themselves in this virtual world. Augmented reality (AR) systems layer virtual information over a live camera feed into...

Solifenacin for children and adolescents with overactive bladders

1 January 2018 | | URO - Basic Science Research, URO - Functional / Reconstructive Urology, URO - Paediatrics
Solifenacin (VESIcare®) is the second-line anti-muscarinic medication of choice for my patients with overactive bladder (oxybutynin being my initial choice). However, currently, it remains unlicensed for use in children. Newgreen et al. have evaluated the long-term safety and efficacy of...

Cortical stimulation for voiding dysfunction in multiple sclerosis

12 October 2022 | | URO - Functional / Reconstructive Urology, URO - Neurourology
Voiding dysfunction (VD) increases morbidity in patients with multiple sclerosis (MS), and may be associated with urinary tract infections, stones and renal failure. Catheterisation is required when impaired hand function precludes self-catheterisation, which is associated with further morbidity. In this...

Can dogs smell prostate cancer?

4 March 2025 | | URO - Urologic Oncology
For centuries we have known that man’s best friend has an exceptional sense of smell. ‘Sniffer’ dogs are found in a wide range of roles, including drug and explosive detection as part of airport security, helping emergency services locate survivors...

Sepsis syndrome in urology

1 November 2015 | | URO - Infection
There are approximately 100,000 cases of sepsis per year in the UK, of which 37,000 result in death (this is more than prostate cancer, breast cancer, HIV / AIDS and road traffic accidents combined). Urosepsis is defined as sepsis caused...

History of prostate biopsy – part 1

1 January 2018 | | URO - Basic Science Research, URO - Urologic Oncology, URO - Technology
Part 2 of this topic is available here. Prostate biopsy (PBx) to exclude cancer has been part of clinical practice since the beginning of the 20th Century. PBx techniques have evolved over time to optimally address some of the unique...

Nurse practitioner TRUS biopsy: training and preparation

1 May 2014 | | URO - Urologic Oncology
As prostate cancer rates increase, many urology departments rely on multi-professional teams to diagnose and manage patients with prostate cancer. The aim of this article is to highlight the skills, training and preparation required for nurse practitioners to undertake trans-rectal...

The NICE Guideline on Urinary Incontinence: the management of urinary incontinence in women

1 May 2014 | | URO - Functional / Reconstructive Urology
Background Urinary incontinence (UI) is a common symptom that can affect women of all ages. It is difficult to estimate the prevalence of UI since it is often under-reported, although the Norwegian EPINCONT study looking at women over 20 reported...

Intravesical GAG replacement therapies for bladder pain syndrome / interstitial cystitis – an update

4 May 2020 | | URO - Functional / Reconstructive Urology, URO - Infection, URO - Basic Science Research
The barrier function of the glycosaminoglycan (GAG) layer of the urothelium was identified by Parsons in 1975, and intravesical therapies to treat chronic inflammatory conditions of the bladder were developed soon after. However, the active role of the urothelium in...

ACP Annual Conference 2026

11 May 2026 -12 May 2026
The Association for Continence Professionals (ACP) is proud to invite you to our annual conference, set in the historic city of Edinburgh on 11-12 May 2026. Join us for a celebration of excellence and evolution in continence care. Honouring 45...